Molecular docking studies of BCL- 2 with Erythroxylum monogynum Roxb. compounds for anti inflammatory studies

Molecular docking studies on interaction of Annona muricata compounds with antiapoptotic proteins Bcl-2 and survivin

Cancer is referred to as uncontrolled growth of normal cell mass. Bcl-2 and survivin are important regulatory protein molecules involved in cell cycle regulation. The protein ligand interaction plays a significant role in structure based drug designing. The present study was aimed to evaluate the interaction of Annona muricata compounds with target proteins (Bcl-2 and survivin) using in silico ...

Synthesis, anti-inflammatory, analgesic, COX1/2-inhibitory activity, and molecular docking studies of hybrid pyrazole analogues

This article reports on the design, synthesis, and pharmacological activity of a new series of hybrid pyrazole analogues: 5a-5u. Among the series 5a-5u, the compounds 5u and 5s exhibited potent anti-inflammatory activity of 80.63% and 78.09% and inhibition of 80.87% and 76.56% compared with the standard drug ibuprofen, which showed 81.32% and 79.23% inhibition after 3 and 4 hours, respectively....

Molecular Docking Studies of withania compounds and their derivatives as Bcl-2 inhibitors in comparison to ginsenosides

Identification of potential anti-inflammatory bioactive compounds from Withania somnifera (L.) Dunal: Molecular docking studies using Glide

Non-steroidal anti-inflammatory drugs and COX-2 inhibitors bind to COX-2 and provide relief from the symptoms of pain and inflammation. However, they lack anti-thrombotic activity and hence lead to cardiovascular and renal liabilities apart from gastrointestinal irritation. J Martel-Pelletier et al. reported that dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act ...

Pharmacokinetics and Molecular Docking studies of Plant-Derived Natural Compounds to Exploring Potential Anti-Alzheimer Activity

Alzheimer's disease (AD) is the leading cause of dementia, accounts for 60 to 80 percent cases. Two main factors called β-amyloid (Aβ) plaques and tangles are prime suspects in damaging and killing nerve cells. However, oxidative stress, the process which produces free radicals in cells, is believed to promote its progression to the extent that it may responsible for the cognitive and functiona...